明胶
三元运算
材料科学
动态力学分析
甘油
辐照
弹性模量
自愈水凝胶
化学工程
生物材料
复合材料
生物医学工程
聚合物
高分子化学
化学
纳米技术
有机化学
核物理学
工程类
程序设计语言
物理
医学
计算机科学
作者
Yantao Zhao,Han Li,Jun Yan,Zhonghai Li,Fuli Wang,Yang Xia,Shuxun Hou,Hongshan Zhong,Feimin Zhang,Ning Gu
标识
DOI:10.1002/adhm.201600749
摘要
Injectable gelatin gels offer an attractive option for filling bone defects. The challenge is to fabricate gelatin gels with optimal gelation properties, which can be irradiation sterilized. Here, a gelatin–water–glycerol (GWG) gel is reported for use as a broad‐spectrum injectable carrier. This ternary gel is high in glycerol and low in water, and remains stable after gamma irradiation at doses (25 kGy). As an injectable gel, it remains a viscous solution at gelatin concentrations ≤2.0%, at room temperature. Its storage modulus increases dramatically and eventually exceeds the loss modulus around 46–50 °C, indicating a transition from a liquid‐like state to an elastic gel‐like state. This ternary gel ranges significantly in terms of storage modulus (12–1700 Pa) while demonstrating a narrow pH range (5.58–5.66), depending on the gelatin concentration. Therefore, it can be loaded with a variety of materials. It is highly cytocompatible compared with saline in vivo and culture media in vitro. When loaded with demineralized bone matrix, the composites show favorable injectability, and excellent osteogenesis performance, after irradiation. These features can be attributed to high hydrophilicity and fast degradability. These findings justify that this ternary gel is promising as an irradiation‐sterilized and universal injectable delivery system.
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