医学
胸腺瘤
胸腺癌
危险系数
比例危险模型
阶段(地层学)
倾向得分匹配
癌症
放射治疗
内科学
外科
多元分析
单变量分析
肿瘤科
置信区间
古生物学
生物
作者
Mary Jackson,David A. Palma,D. Ross Camidge,Bernard L. Jones,Tyler P. Robin,David J. Sher,Matthew Koshy,Brian D. Kavanagh,Laurie E. Gaspar,Chad G. Rusthoven
标识
DOI:10.1016/j.jtho.2017.01.002
摘要
IntroductionThe optimal role for postoperative radiotherapy (PORT) for thymoma and thymic carcinoma remains controversial. We used the National Cancer Data Base to investigate the impact of PORT on overall survival (OS).MethodsPatients who underwent an operation for thymoma or thymic carcinoma were categorized into Masaoka-Koga stage groups I to IIA, IIB, III, and IV. Patients who did not undergo an operation or those who received preoperative radiation were excluded. Kaplan-Meier estimates of OS and univariate and multivariate Cox proportional hazards regression analyses were performed. Propensity score–matched analyses were performed to further control for baseline confounders.ResultsFrom 2004 to 2012, 4056 patients were eligible for inclusion, 2001 of whom (49%) received PORT. On multivariate analysis of OS in the thymoma cohort adjusted for age, WHO histologic subtype, Masaoka-Koga stage group, surgical margins, and chemotherapy administration, PORT was associated with superior OS (hazard ratio [HR] = 0.72, p = 0.001). Propensity score–matched analyses confirmed the survival advantage associated with PORT. Subset analysis indicated longer OS in association with PORT for patients with stage IIB thymoma (HR = 0.61, p = 0.035), stage III (HR = 0.69, p = 0.020), and positive margins (HR = 0.53, p < 0.001). The impact of PORT for stage I to IIA disease did not reach significance (HR = 0.76, p = 0.156).ConclusionsIn this large database analysis of PORT for thymic tumors, PORT was associated with longer OS, with the greatest relative benefits observed for stage IIB to III disease and positive margins. In the absence of randomized studies assessing the value of PORT, these data may inform clinical practice.
科研通智能强力驱动
Strongly Powered by AbleSci AI