医学
急性呼吸窘迫综合征
潮气量
体外膜肺氧合
呼气末正压
肺顺应性
电阻抗断层成像
机械通风
麻醉
体外
充氧
顺从(心理学)
肺容积
肺
心脏病学
通风(建筑)
内科学
呼吸系统
断层摄影术
放射科
工程类
机械工程
社会心理学
心理学
作者
Guillaume Franchineau,Nicolas Bréchot,Guillaume Lebreton,Guillaume Hékimian,Ania Nieszkowska,Jean‐Louis Trouillet,Pascal Leprince,Jean Chastre,Charles‐Édouard Luyt,Alain Combes,Matthieu Schmidt
标识
DOI:10.1164/rccm.201605-1055oc
摘要
Rationale: Optimal positive end-expiratory pressure (PEEP) is unknown in patients with severe acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation receiving mechanical ventilation with very low tidal volume.Objectives: To evaluate the ability of electrical impedance tomography (EIT) to monitor a PEEP trial and to derive from EIT the best compromise PEEP in this setting.Methods: A decremental PEEP trial (20–0 cm H2O) in 5 cm H2O steps was monitored by EIT, with lung images divided into four ventral-to-dorsal horizontal regions of interest. The EIT-based PEEP providing the best compromise between overdistention and collapsed zones was arbitrarily defined as the lowest pressure able to limit EIT-assessed collapse to less than or equal to 15% with the least overdistention. Driving pressure was maintained constant at 14 cm H2O in pressure controlled mode.Measurements and Main Results: Tidal volume, static compliance, tidal impedance variation, end-expiratory lung impedance, and their respective regional distributions were visualized at each PEEP level in 15 patients on extracorporeal membrane oxygenation. Low tidal volume (2.9–4 ml/kg ideal body weight) and poor compliance (12.1–18.7 ml/cm H2O) were noted, with significantly higher tidal volume and compliance at PEEP10 and PEEP5 than PEEP20. EIT-based best compromise PEEPs were 15, 10, and 5 cm H2O for seven, six, and two patients, respectively, whereas PEEP20 and PEEP0 were never selected.Conclusions: The broad variability in optimal PEEP observed in these patients with severe ARDS under extracorporeal membrane oxygenation reinforces the need for personalized titration of ventilation settings. EIT may be an interesting noninvasive bedside tool to provide real-time monitoring of the PEEP impact in these patients.
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