对映选择合成
化学
催化作用
表面改性
回顾性分析
立体选择性
组合化学
过渡金属
劈理(地质)
反应性(心理学)
立体化学
计算化学
纳米技术
有机化学
全合成
物理化学
病理
工程类
医学
断裂(地质)
岩土工程
材料科学
替代医学
作者
Christopher G. Newton,Shouguo Wang,Caio C. Oliveira,Nicolai Cramer
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2017-02-17
卷期号:117 (13): 8908-8976
被引量:811
标识
DOI:10.1021/acs.chemrev.6b00692
摘要
The development of new methods for the direct functionalization of unactivated C–H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic enantioselective functionalization of C–H bonds represents a highly atom- and step-economic approach toward the generation of structural complexity. However, as a result of their ubiquity and low reactivity, controlling both the chemo- and stereoselectivity of such processes constitutes a significant challenge. Herein we comprehensively review all asymmetric transition-metal-catalyzed methodologies that are believed to proceed via an inner-sphere-type mechanism, with an emphasis on the nature of stereochemistry generation. Our analysis serves to document the considerable and rapid progress within in the field, while also highlighting limitations of current methods.
科研通智能强力驱动
Strongly Powered by AbleSci AI