化学
黄酮类
吗啉
细胞毒性
MTT法
立体化学
细胞培养
彗星试验
对接(动物)
组合化学
细胞生长
生物化学
DNA
体外
DNA损伤
有机化学
医学
护理部
色谱法
生物
遗传学
作者
Lata C. Potey,Prafulla M. Sabale,Vidya Sabale
出处
期刊:Letters in Drug Design & Discovery
[Bentham Science]
日期:2023-10-01
卷期号:20 (10): 1610-1620
标识
DOI:10.2174/1570180819666220919124717
摘要
Background: Cancer is a complex disease in which some of the cells grow uncontrollably and spread to other parts of the body. Objective: The present study focuses on molecular docking and synthesis of novel flavone derivatives substituted with heterocyclic rings. Objective: The present study focuses on molecular docking and synthesis of novel flavone derivatives substituted with heterocyclic rings. Methods: The anticancer activity of novel flavones against human aromatase enzyme using human breast cancer cell line MCF-7 through MTT assay was demonstrated. The synthesized compounds for the determination of single or double-strand DNA damage through the single-cell electrophoresis/comet assay were evaluated. Results: In this study, we found that the derivative 3M with Morpholine ring showed the highest anticancer potency against the MCF-7 cell line compared to that of other flavone derivatives. Compound 3T showed less cytotoxicity against the MCF-7 cell line. Conclusion: Based on the findings, flavone scaffolds can be selected as a skeleton for the development of heterocyclic amine-containing flavones with the potential to develop as anticancer drugs.
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