造血
微生物群
干细胞
免疫学
造血干细胞移植
造血干细胞
生物
免疫系统
疾病
血液病
血液病
祖细胞
医学
生物信息学
内科学
遗传学
作者
Josaura Fernandez Sanchez,Arushana Maknojia,Katherine Y. King
出处
期刊:Blood
[American Society of Hematology]
日期:2024-02-16
卷期号:143 (17): 1689-1701
被引量:1
标识
DOI:10.1182/blood.2023021174
摘要
Abstract Over the past 10 years, there has been a marked increase in recognition of the interplay between the intestinal microbiome and the hematopoietic system. Despite their apparent distance in the body, a large literature now supports the relevance of the normal intestinal microbiota to steady-state blood production, affecting both hematopoietic stem and progenitor cells as well as differentiated immune cells. Microbial metabolites enter the circulation where they can trigger cytokine signaling that influences hematopoiesis. Furthermore, the state of the microbiome is now recognized to affect outcomes from hematopoietic stem cell transplant, immunotherapy, and cellular therapies for hematologic malignancies. Here we review the mechanisms by which microbiotas influence hematopoiesis in development and adulthood as well as the avenues by which microbiotas are thought to impact stem cell transplant engraftment, graft-versus-host disease, and efficacy of cell and immunotherapies. We highlight areas of future research that may lead to reduced adverse effects of antibiotic use and improved outcomes for patients with hematologic conditions.
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