视神经脊髓炎
光谱紊乱
医学
怀孕
多发性硬化
疾病
儿科
产后
人口
产科
免疫学
内科学
精神科
遗传学
生物
环境卫生
作者
Pakeeran Siriratnam,Saif Huda,Helmut Butzkueven,Anneke van der Walt,Vilija Jokubaitis,Mastura Monif
标识
DOI:10.1016/j.autrev.2023.103499
摘要
Neuromyelitis optica spectrum disorder (NMOSD) is a rare central nervous system autoimmune disease. Aquaporin-4 antibody (AQP4-IgG) is present in over 75% of cases and criteria also exist for the diagnosis of seronegative NMOSD. AQP4-IgG NMOSD has a strong female predominance (9:1 ratio), with a median onset age of 40 years. Pregnancy in those with NMOSD is therefore an important topic. Fecundity in NMOSD is likely impaired, and for females who conceive, obstetric complications including miscarriages and pre-eclampsia are significantly higher in NMOSD compared to the general population and in related conditions such as multiple sclerosis (MS). In contrast to MS, NMOSD disease activity does not subside during pregnancy. Also, relapse risk substantially rises above pre-pregnancy rates in the early postpartum period. In view of the evolving landscape of NMOSD, we provide a contemporary update of the impacts of pregnancy in NMOSD.
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