间隙
药代动力学
药效学
泌尿系统
抗菌剂
医学
尿
药理学
抗生素
生物
内科学
微生物学
泌尿科
作者
Katharina Rox,Rolf Jansen,Tadeja Lukežič,Marina C. Greweling‐Pils,Jennifer Herrmann,Marcus Miethke,Stephan Hüttel,Fabienne Hennessen,Antoine Abou Fayad,Cornelia Holzhausen,Carina Vingsbo Lundberg,Joanne Teague,Enge Sudarman,Lisa Bülter,Thomas Hesterkamp,Marc Stadler,Mark Brönstrup,Rolf Müller
标识
DOI:10.1128/spectrum.01289-23
摘要
There is a strong need to find novel treatment options against urinary tract infections associated with antimicrobial resistance. This study evaluates two atypical tetracyclines, namely chelocardin (CHD) and amidochelocardin (CDCHD), with respect to their pharmacokinetics and pharmacodynamics. We show CHD and CDCHD are cleared at high concentrations in mouse urine. Especially, CDCHD is highly effective in an ascending urinary tract infection model, suggesting further preclinical evaluation.
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