Dietary limonin ameliorates heart failure with preserved ejection fraction by targeting ferroptosis via modulation of the Nrf2/SLC7A11/GPX4 axis: an integrated transcriptomics and metabolomics analysis

Limonin ameliorates HFpEF by attenuating cardiac remodeling while inhibiting ferroptosis through activation of the Nrf2/SLC7A11/GPX4 axis and inhibition of ACSL4/COX2/ALOXs-mediated lipid peroxidation, as validated by multi-omics analyses.