Enantio- and Diastereoselective Synthesis of P-Stereogenic Phospholane Oxides via Cobalt-Catalyzed Hydroalkylation

Chiral phospholane ligands and catalysts have been widely applied in asymmetric catalysis and synthesis. However, the construction of the chiral phospholane skeleton remains challenging and primarily relies on the use of chiral auxiliaries or resolution. In this work, a highly enantioselective and diastereoselective synthesis of P-stereogenic phospholane oxides has been achieved through a cobalt-catalyzed desymmetric hydroalkylation strategy. This method enables the construction of two discrete stereocenters with excellent yields and enantiomeric excesses.