Glymphatic dysfunction is related to motor disability fully mediated by gray matter degeneration in early-stage Parkinson's disease

Glymphatic dysfunction in early-stage PD correlates with GM degeneration and motor decline. Left posterior cingulate degeneration fully mediates the impact of glymphatic dysfunction on motor disability. These findings deepen the understanding of the clinical relevance of glymphatic dysfunction and provide further insights into the regulatory mechanisms underlying PD-related neurodegenerative circuits.