Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment

T cells, along with promoting dendritic cell (DC) maturation and synergistically enhancing ICB efficacy. With the high specificity of SAR405 and the controllable therapeutic process under LIFU irradiation, this noninvasive, efficient, and cost-effective drug delivery vector opened new horizons for conquering the clinical dilemma of rescuing ICB response rates.