Three bioactive dibenzocyclooctadiene lignans from the fruits of Kadsura coccinea

Three new dibenzocyclooctadiene lignans, namely, kadcolignan H-J (1-3), were isolated from the ethanol extract of Kadsura coccinea fruits. Their molecular structures, including absolute configurations, were elucidated through comprehensive spectroscopic analyses. The hepatoprotective effects of kadcolignan H-J (1-3) were subsequently evaluated. Both kadcolignan H (1) and kadcolignan J (3) demonstrated inhibitory effects on triglyceride and total cholesterol levels, whereas all isolated compounds effectively reduced the levels of free fatty acids-induced reactive oxygen species in HepG2 cells.