Comparative analysis of the vaginal microbiome of healthy and polycystic ovary syndrome women: a large cross-sectional study

多囊卵巢 乳酸菌 普雷沃菌属 微生物群 嗜酸乳杆菌 生物 睾酮(贴片) 妇科 生理学 内科学 内分泌学 医学 生物信息学 遗传学 益生菌 细菌 糖尿病 胰岛素抵抗
作者
Congcong Jin,Lang Qin,Zheng Liu,Xiao Li,Xuan Gao,Yongzhi Cao,Shigang Zhao,Jiaojiao Wang,Ting Han,Lei Yan,Jialun Song,Fangfang Zhang,Feifei Liu,Yousheng Zhang,Yuzhen Huang,Yuping Song,Yanjun Liu,Zhina Yao,Honglei Chen,Zhenzhen Zhang,Shengrui Zhao,Yuhan Feng,Yanan Zhang,Qian Yu,Tianyong Sun,Qiang Feng,Han Zhao
出处
期刊:Reproductive Biomedicine Online [Elsevier BV]
卷期号:46 (6): 1005-1016 被引量:6
标识
DOI:10.1016/j.rbmo.2023.02.002
摘要

What are the different features of the vaginal microbiome (VMB) between patients with polycystic ovary syndrome (PCOS) and healthy women?A cross-sectional study was conducted at a single academic university-affiliated centre. A total of 1446 participants were recruited (PCOS group, n =713, control group, n = 733). Vaginal swabs were analysed using 16S rRNA gene sequencing. The diversity and composition of the microbiome were compared between the PCOS group and the control group. Microbial interaction networks and functional prediction were investigated.The PCOS group had a higher alpha diversity than the control group (Shannon P = 0.03, Simpson P = 0.02), and higher intra-group variability was observed in PCOS group (P < 2.2E-16). At the genus level, the proportion of Lactobacillus decreased (85.1% versus 89.3%, false discovery rate [FDR] = 0.02), whereas the proportion of Gardnerella vaginalis and Ureaplasma increased in the PCOS group (5.1% versus 3.3%, FDR = 0.006; 1.2% versus 0.6%, FDR = 0.002, respectively). Lactobacillus acidophilus, Prevotella buccalis and G. vaginalis were identified as the main differential species. L. acidophilus was positively correlated with serum levels of anti-Müllerian hormone (AMH), and triglyceride (P = 2.01E-05, P = 0.004, respectively). P. buccalis was negatively correlated with serum levels of AMH and testosterone (P = 0.002, P = 0.003, respectively). G. vaginalis was positively correlated with serum levels of AMH, oestradiol and progesterone (P = 0.004, P = 0.005, P = 0.03, respectively). The VMB interaction network indicated that Lactobacillus crispus, Prevotella timonensis, and P. buccalis could be key drivers in the PCOS group. Overall, 55 predicted genes were found to be differentially abundant between PCOS and the control (FDRs < 0.25).The PCOS group had a higher diversity of vaginal microbiome and showed an enhanced level of heterogeneity. The proportion of Lactobacillus in the PCOS group decreased, whereas the proportions of Gardnerella and Ureaplasma increased. These results warrant further research that can validate the correlation between PCOS and VMB.
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