类风湿性关节炎
微流控芯片
微流控
生物素化
抗体
医学
类风湿因子
生物医学工程
材料科学
免疫学
纳米技术
分子生物学
生物
作者
Tsung-Hsien Wu,Yi-Cheng Tsai,Feng-Chih Kuo,Mel S. Lee,Chih-Chien Hu,Gwo‐Bin Lee
标识
DOI:10.1016/j.snb.2023.133587
摘要
Early detection of rheumatoid factors (RF) and cyclic citrullinated peptide antibodies (anti-CCP) has been proven to be effective in diagnosing, and even preventing progression to more advanced-stages, of rheumatoid arthritis (RA), thereby decreasing irreversible damage to joints. Herein a novel, dual-target detection approach was integrated in a 45 mm × 62 mm microfluidic chip that featured a symmetrical design in which magnetic beads surface-coated with fragment-crystallizable regions of immunoglobulin G and biotinylated CCP enabled detection of these two RA biomarkers within 55 min with only 5 μL of serum. This device could therefore be useful for rapid clinical diagnosis of this all-too-common ailment.
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