Development of alginate-based hydrogels: Crosslinking strategies and biomedical applications

Natural polysaccharide-based hydrogels have drawn much concern in the biomedical fields. Among them, alginate, a natural polyanionic polysaccharide, has become one of the research hotspots, because of its abundant source, biodegradability, biocompatibility, solubility, modification flexibility, and other characteristics or physiological functions. Recently, through adopting various physical or chemical crosslinking strategies, selecting suitable crosslinking or modification reagents, precisely controlling the reaction conditions, or introducing organic or inorganic functional materials, a variety of alginate-based hydrogels with excellent performance have been continuously developed, considerably expanding the breadth and depth of their applications. Here, various crosslinking strategies in the preparation of alginate-based hydrogels are comprehensively introduced. The representative application progress of alginate-based hydrogels in drug carrier, wound dressing and tissue engineering is also summarized. Meanwhile, the application prospects, challenges and development trends of alginate-based hydrogels are discussed. It is expected to provide guidance and reference for the further development of alginate-based hydrogels.