化学
氢胺化
区域选择性
对映选择合成
吡唑
催化作用
铜
组合化学
有机化学
药物化学
作者
Minghao Wang,Julie Simon,Mengfei Xu,Stephanie A. Corio,Jennifer S. Hirschi,Vy M. Dong
摘要
Chiral N-cyclopropyl pyrazoles and structurally related heterocycles are prepared using an earth-abundant copper catalyst under mild reaction conditions with high regio-, diastereo-, and enantiocontrol. The observed N2:N1 regioselectivity favors the more hindered nitrogen of the pyrazole. Experimental and DFT studies support a unique mechanism that features a five-centered aminocupration.
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