化学
胍
嘧啶
硫黄
组合化学
级联
相容性(地球化学)
基础(拓扑)
药物化学
立体化学
有机化学
色谱法
化学工程
数学
工程类
数学分析
作者
Juan Wan,Shuntao Huang,Zhen Zhou,Qin Wu,Z. Wang,Chao Huang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-06-09
卷期号:25 (24): 4451-4455
被引量:1
标识
DOI:10.1021/acs.orglett.3c01383
摘要
An unexpected [5 + 1 + 3] cascade cyclization to the preparation of benzo[4,5]thieno[3,2-d]pyrimidine derivatives has been disclosed. In the new protocol, o-nitrochalcones reacted with elemental sulfur and guanidine promoted by NaOH, which reacted in EtOH for 20 min, providing structurally diverse benzo[4,5]thieno[3,2-d]pyrimidines with good yields (77-89%) and wide substrate compatibility (33 examples).
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