化学
铑
催化作用
DNA
组合化学
相容性(地球化学)
立体化学
有机化学
生物化学
化学工程
工程类
作者
Yusong Ye,Madeline Berry,William J. Bock,Kunpeng Cheng,Sajiv K. Nair,C. S. Park,Ryan L. Patman,Sylvie K. Sakata,Michelle Tran‐Dube,Joyann S. Donaldson,Ge Yang,Guansai Liu
标识
DOI:10.1021/acs.orglett.4c00604
摘要
Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium(III)-catalyzed C–H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.
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