骨肉瘤
基因沉默
环状RNA
小RNA
生物
癌症研究
生物标志物
转移
下调和上调
癌症
基因
遗传学
作者
Huijiang Liu,Qian Huang,Haijun Tang,Kai Luo,Yiwu Qin,Feicui Li,Fuxing Tang,Jiqing Zheng,Wei Feng,Boxiang Li,Tianyu Xie,Yun Liu
标识
DOI:10.1089/dna.2022.0500
摘要
Circular RNA (circRNA) is involved in the occurrence and development of various cancers. To this day, the expression and mechanism of circRNA in osteosarcoma (OS) remain unclear. We previously found that circ_0001060 was highly expressed in OS tumor tissues. In this work, we identified that high level expression of circ_0001060 was significantly associated with late clinical stage, larger tumor volume, higher frequency of metastasis, and poor prognosis in OS patients. Furthermore, we confirmed that silencing circ_0001060 inhibited the proliferation and migration of OS cell. Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS. To sum up, circ_0001060 is a novel tumor biomarker for OS as well as a potential therapeutic target.
科研通智能强力驱动
Strongly Powered by AbleSci AI