部分各向异性
心理学
心理理论
精神分裂症(面向对象编程)
白质
下纵束
神经认知
磁共振弥散成像
神经科学
认知
听力学
磁共振成像
医学
精神科
放射科
作者
C. Demirlek,Merve Karakılıç,Emre Sarıkaya,Adem Bayrakçı,Burcu Verim,Funda Gülyüksel,Berna Yalınçetin,Elif Oral,Fazıl Gelal,Nabi Zorlu,Emre Bora
标识
DOI:10.1016/j.pscychresns.2023.111744
摘要
Theory of mind skills are disrupted in schizophrenia. However, various theory of mind tasks measure different neurocognitive domains. This multimodal neuroimaging study aimed to investigate the neuroanatomical correlates of mental state decoding and reasoning components of theory of mind in schizophrenia and healthy controls (HCs) using T1-weighted and diffusion-weighted (DTI) magnetic resonance imaging (MRI). Sixty-two patients with schizophrenia and 34 HCs were included. The Reading the Mind in the Eyes (RMET) and Hinting tests were used to evaluate mental state decoding and reasoning, respectively. Correlations between social cognition and cortical parameters (thickness, volume, surface area), or DTI scalars (fractional anisotropy, axial diffusivity, radial diffusivity) were cluster-based corrected for multiple comparisons. In schizophrenia, RMET scores showed positive correlations in 3 clusters, including left insula thickness, right superior-temporal thickness, left superior-temporal-sulcus volume, and DTI analysis revealed that fractional anisotropy showed positive correlations in 3 clusters, including right inferior-fronto-occipital fasciculus, left forceps-major, left inferior-fronto-occipital fasciculus. In schizophrenia, Hinting test scores showed positive correlations in 3 clusters in T1-weighted MRI, including left superior-temporal-sulcus volume, left superior-temporal-sulcus surface area, left pars-orbitalis volume. In conclusion, this study provided evidence for the involvement of particular cortical regions and white matter tracts in mental state decoding and reasoning.
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