光降解
紫外线滤光片
光防护
芦丁
分散性
材料科学
色谱法
化学
有机化学
抗氧化剂
光催化
生物化学
高分子化学
物理
光合作用
光学
催化作用
作者
Rodrigo Martins,Silvia de Siqueira Martins,Gustavo Luis Ferreira Barbosa,Eullállia Gonçalo das Neves e Silva,Maria José Vieira Fonseca,Luís Freitas
标识
DOI:10.1016/j.jddst.2023.104860
摘要
A topical formulation containing a natural compound (rutin), in association with UVA filter solid lipid microparticles (SLMs) was prepared aiming to decrease the photodegradation of the UV filter and evaluate whether the sunscreen's photoprotection was impaired by the microencapsulation process caused by UVA radiation. The SLMs were manufactured by spray congealing using a factorial central composite design. The optimum conditions for the preparation were a UVA filter content of 60.5%, flow rate of 6.76 mL/min, and airflow rate of 2.84 m³/min. SLMs presented a mean size of 29.6 μm, polydispersity index of 1.74, encapsulation efficiency of 100%. The topical formulation showed that the microencapsulation process and the free rutin were able to reverse avobenzone photodegradation. In addition, the formulation promoted photoprotection, showing that the microencapsulation process associated with the rutin is promising for use in sunscreens.
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