环加成
化学
亲核细胞
氧化剂
试剂
铬
反应性(心理学)
组合化学
吲哚试验
吲哚
光催化
药物化学
光化学
催化作用
有机化学
医学
替代医学
病理
作者
Bradley K. Gall,Avery K. Smith,Eric M. Ferreira
标识
DOI:10.1002/ange.202212187
摘要
Abstract A direct dearomative photocatalyzed (3+2) cycloaddition between indoles and vinyldiazo reagents is described. The transformation is enabled by the development of a novel oxidizing Cr III photocatalyst, its specific reactivity attributed to increased absorptive properties over earlier Cr analogs and greater stability than Ru counterparts. A variety of fused indoline compounds are synthesized using this method, including densely functionalized ring systems that are feasible due to base‐free conditions. Experimental insights corroborate a cycloaddition initiated by nucleophilic attack at C3 of the indole radical cation by the vinyldiazo species.
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