肌萎缩
肠道菌群
炎症
氧化应激
肌肉蛋白
生物
粪便
握力
骨骼肌
乳酸菌
下调和上调
内分泌学
内科学
免疫学
医学
低蛋白饮食
微生物群
蛋白质饮食
生理学
腓肠肌
膳食蛋白质
S100A8型
益生菌
蛋氨酸
细菌
代谢综合征
肠道细菌
高蛋白饮食
作者
Dengfeng Xu,Qi Xu,Jiarui Lu,Yamin Chen,Bingmeng Fu,Xue Zhang,Xuefeng Qu,Yangjunna Zhang,Jingjin Hu,Shuguang Fang,Yu Wang
摘要
This study examined whether a plant-derived protein diet combined with multi-strain probiotics protects against sarcopenia in naturally aged rats (21 months old) via the gut-muscle axis following a 12-week intervention.Compared with the aged control group,The combined intervention increased grip strength by 55.96%, gastrocnemius index by 23.49%, and quadriceps index by 28.29%, while reducing oxidative stress and inflammation (MDA by 39.80%, TNF-α by 42.19%, IL-6 by 65.81%). Mechanistically, it enhanced gut microbiota diversity, enriched beneficial taxa (e.g., Alistipes, Lachnospiraceae_UCG-006), elevated fecal SCFAs, modulated serum amino acids, and upregulated muscle synthesis-related proteins (AMPK-α1, p70 S6K). These findings suggest that a plant-derived protein diet supplemented with multi-strain probiotics represents a promising nutritional strategy to counteract age-related sarcopenia and support healthy ageing.
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