材料科学
药物输送
电容感应
生物医学工程
纳米技术
电阻式触摸屏
计算机科学
医学
计算机视觉
操作系统
作者
Kaveti Rajaram,Joong Hoon Lee,Joong Kee Youn,Tae‐Min Jang,Won Bae Han,Seung Min Yang,Jeong‐Woong Shin,Gwan‐Jin Ko,Dong‐Je Kim,Sungkeun Han,Heeseok Kang,Amay J. Bandodkar,Sujeong Kim,Suk‐Won Hwang
标识
DOI:10.1002/adma.202307391
摘要
Current research in the area of surgical mesh implants is somewhat limited to traditional designs and synthesis of various mesh materials, whereas meshes with multiple functions may be an effective approach to address long-standing challenges including postoperative complications. Herein, a bioresorbable electronic surgical mesh is presented that offers high mechanical strength over extended timeframes, wireless post-operative pressure monitoring, and on-demand drug delivery for the restoration of tissue structure and function. The study of materials and mesh layouts provides a wide range of tunability of mechanical and biochemical properties. Dissolvable dielectric composite with porous structure in a pyramidal shape enhances sensitivity of a wireless capacitive pressure sensor, and resistive microheaters integrated with inductive coils provide thermo-responsive drug delivery system for an antibacterial agent. In vivo evaluations demonstrate reliable, long-lived operation, and effective treatment for abdominal hernia defects, by clear evidence of suppressed complications such as adhesion formation and infections.
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