生物制造
细胞外小泡
微泡
炎症
细胞外
胞外囊泡
生物
纳米技术
细胞生物学
计算生物学
微生物学
免疫学
生物技术
材料科学
生物化学
小RNA
基因
作者
Daniel Levy,Talia Solomon,Steven M. Jay
标识
DOI:10.1016/j.copbio.2024.103067
摘要
Extracellular vesicles (EVs) are an emergent next-generation biotechnology with broad application potential. In particular, immunomodulatory bioactivity of EVs leading to anti-inflammatory effects is well-characterized. Cell source and culture conditions are critical determinants of EV therapeutic efficacy, while augmenting EV anti-inflammatory bioactivity via diverse strategies, including RNA cargo loading and protein surface display, has proven effective. Yet, translational challenges remain. Additionally, the potential of direct antimicrobial EV functionality has only recently emerged but offers the possibility of overcoming drug-resistant bacterial and fungal infections through novel, multifactorial mechanisms. As discussed herein, these application areas are brought together by the potential for synergistic benefit from technological developments related to EV cargo loading and biomanufacturing.
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