光热治疗
细胞凋亡
光动力疗法
纳米颗粒
化学
程序性细胞死亡
活性氧
肿瘤细胞
癌症研究
生物物理学
纳米技术
细胞生物学
材料科学
医学
生物
生物化学
有机化学
作者
Muse Ji,Hongbing Liu,Xinxin Liang,Mingli Wei,Dongmei Shi,Jingxin Gou,Tian Yin,Haibing He,Xing Tang,Yu Zhang
标识
DOI:10.1016/j.cej.2024.149640
摘要
Combination therapy harnessing multiple cell death mechanisms has emerged as a promising approach for cancer treatment. However, the optimization of therapeutic synergies when integrating different modalities remained a challenge. In response, we have developed a multifunctional copper (Cu)-based metal–organic framework (MOF) nanoparticle loaded with mitoxantrone (MTO) and axitinib (AXB) incorporating tumor cell membrane (termed as M/A@MOF@CM) for synergistic cuproptosis/ferroptosis/apoptosis anticancer therapy. M/A@MOF@CM exhibited a diverse range of therapeutic activities, such as chemotherapy, photothermal therapy (PTT), and chemodynamic therapy (CDT), thereby enhancing immunogenic cell death (ICD) for potential immunotherapy. As a consequence, the comprehensive approach led to a substantial 86.45 % inhibition in primary tumor and a noteworthy 65.61 % suppression in distant tumors. This work constructs a multifunctional MOF nanoparticle, achieving "tumor cells are under siege from all sides", which potentially ushers in a new era in the realm of MOF-based synergistic cancer therapy platforms.
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