活性氧
氧化应激
细胞信号
细胞生物学
生物
信号转导
转录因子
生物化学
基因
作者
Yuhang Hong,Alessandra Boiti,Daniela Vallone,Nicholas S. Foulkes
出处
期刊:Antioxidants
[MDPI AG]
日期:2024-03-01
卷期号:13 (3): 312-312
标识
DOI:10.3390/antiox13030312
摘要
Since the evolution of the aerobic metabolism, reactive oxygen species (ROS) have represented significant challenges to diverse life forms. In recent decades, increasing knowledge has revealed a dual role for ROS in cell physiology, showing they serve as a major source of cellular damage while also functioning as important signaling molecules in various biological processes. Our understanding of ROS homeostasis and ROS-mediated cellular signaling pathways has presumed that they are ancient and highly conserved mechanisms shared by most organisms. However, emerging evidence highlights the complexity and plasticity of ROS signaling, particularly in animals that have evolved in extreme environments. In this review, we focus on ROS generation, antioxidative systems and the main signaling pathways that are influenced by ROS. In addition, we discuss ROS's responsive transcription regulation and how it may have been shaped over the course of evolution.
科研通智能强力驱动
Strongly Powered by AbleSci AI