软骨细胞
软骨内骨化
肌肉肥大
细胞生物学
骨生长
骨化中心
化学
形态发生
细胞生长
解剖
材料科学
生物物理学
骨化
生物
软骨
内分泌学
生物化学
基因
作者
Yuka Yokoyama,Yoshitaka Kameo,Junko Sunaga,Kosuke Maki,Taiji Adachi
出处
期刊:Bone
[Elsevier]
日期:2024-05-01
卷期号:182: 117055-117055
标识
DOI:10.1016/j.bone.2024.117055
摘要
The length of long bones is determined by column formation of proliferative chondrocytes and subsequent chondrocyte hypertrophy in the growth plate during bone development. Despite the importance of mechanical loading in long bone development, the mechanical conditions of the cells within the growth plate, such as the stress field, remain unclear owing to the difficulty in investigating spatiotemporal changes within dynamically growing tissues. In this study, the mechanisms of longitudinal bone growth were investigated from a mechanical perspective through column formation of proliferative chondrocytes within the growth plate before secondary ossification center formation using continuum-based particle models (CbPMs). A one-factor model, which simply describes essential aspects of a biological signaling cascade regulating cell activities within the growth plate, was developed and incorporated into CbPM. Subsequently, the developmental process and maintenance of the growth plate structure and resulting bone morphogenesis were simulated. Thus, stress anisotropy in the proliferative zone that affects bone elongation through chondrocyte column formation was identified and found to be promoted by chondrocyte hypertrophy. These results provide further insights into the mechanical regulation of multicellular dynamics during bone development.
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