The role of short-chain fatty acids in the formation of non-alcoholic fatty liver disease in children: A review

This review examines scientific publications that describe the main properties of microbiota metabolites and their participation in the pathogenetic connection of the intestinal-liver system in children with non-alcoholic fatty liver disease (NAFLD). Normal metabolism of short-chain fatty acids (SCFA) is one of the main conditions for maintaining microbiocinosis, eliminating the main pathological trigger factors. Changes in the qualitative and quantitative characteristics of SCFA can play a significant role in the development of complications in NAFLD. Studying the role of SCFAs in NAFLD in childhood will answer questions about their participation in the main links in the pathogenesis of metabolic and cardiovascular diseases, such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. The data obtained are necessary for the development of personalized correction of the species composition of microorganisms and their metabolites at the initial stages of the disease before the development of significant fibrogenesis.