电泳剂
化学
三氟甲基
芳基
亲核细胞
催化作用
镍
三氟甲基化
组合化学
功能群
硝基
药物化学
光化学
有机化学
烷基
聚合物
作者
Lorenzo Lombardi,Alessandro Cerveri,Riccardo Giovanelli,Marta Castiñeira Reis,Carlos Silva López,Giulio Beertuzzi,Marco Bandini
标识
DOI:10.1002/anie.202211732
摘要
A nickel-catalyzed reductive cross-electrophile coupling between the redox-active N-trifluoroethoxyphthalimide and iodoarenes is documented. The protocol reproduces a formal arylation of trifluoroacetaldehyde under mild conditions in high yields (up to 88 %) and with large functional group tolerance (30 examples). A combined computational and experimental investigation revealed a pivotal solvent assisted 1,2-Hydrogen Atom Transfer (HAT) process to generate a nucleophilic α-hydroxy-α-trifluoromethyl C-centered radical for the Csp2 -Csp3 bond forming process.
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