生物
基因组
人病毒体
生态系统
进化生物学
人口
生态学
寄主(生物学)
遗传学
基因
人口学
社会学
作者
Yunha Hwang,Simon Roux,Clément Coclet,Sebastian J. E. Krause,Peter R. Girguis
出处
期刊:Nature microbiology
日期:2023-04-06
卷期号:8 (5): 946-957
被引量:13
标识
DOI:10.1038/s41564-023-01347-5
摘要
Many microbes in nature reside in dense, metabolically interdependent communities. We investigated the nature and extent of microbe-virus interactions in relation to microbial density and syntrophy by examining microbe-virus interactions in a biomass dense, deep-sea hydrothermal mat. Using metagenomic sequencing, we find numerous instances where phylogenetically distant (up to domain level) microbes encode CRISPR-based immunity against the same viruses in the mat. Evidence of viral interactions with hosts cross-cutting microbial domains is particularly striking between known syntrophic partners, for example those engaged in anaerobic methanotrophy. These patterns are corroborated by proximity-ligation-based (Hi-C) inference. Surveys of public datasets reveal additional viruses interacting with hosts across domains in diverse ecosystems known to harbour syntrophic biofilms. We propose that the entry of viral particles and/or DNA to non-primary host cells may be a common phenomenon in densely populated ecosystems, with eco-evolutionary implications for syntrophic microbes and CRISPR-mediated inter-population augmentation of resilience against viruses.
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