清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

(741) Impact of Frailty on Mortality, Length of Stay, and Resource Utilization after Advanced Heart Failure Therapy

医学 心力衰竭 凝血病 糖尿病 内科学 脑病 队列 回顾性队列研究 内分泌学
作者
M. Mohamad Alahmad
出处
期刊:Journal of Heart and Lung Transplantation [Elsevier]
卷期号:42 (4): S327-S327
标识
DOI:10.1016/j.healun.2023.02.755
摘要

PurposeFrailty has been associated with inferior outcomes in patients with advanced heart failure (HF) therapy, which includes heart transplantation and Left Ventricular Assist Device implantation (LVAD). There is a lack of data to assess if hospital frailty risk score (HFS) is associated with worse outcomes in such populations.MethodsOur retrospective study used Nationwide Readmission Database (NRD). First, we extracted all cases older than 18 years that received advanced heart failure therapy during the index admission between Jan-Jun for 2016-2019 to allow for a 6-month follow-up. Appropriate survey and domain analyses were applied to obtain national estimates using SAS 9.4.ResultsWe identified 14,837 discharges who received advanced HF therapy. HFS <5 was present in 25% (n=3,753) of the cohort. Patients with intermediate-high frailty risk score (HFS<=5) were slightly older than those with low frailty risk (HFS<5) with a mean age of 56 years vs. 54 years, and had fewer women (23% vs. 27%, p<0.001). Patients with HFS>5 had a higher prevalence of diabetes mellitus, cerebrovascular disease (CBVD), acute encephalopathy, anemia, coagulopathy, peripheral vascular disease (PVD), and chronic (liver and renal) diseases (p<0.001). Also, they had higher inpatient mortality during index admission (11% vs. 3%, p<0.001), and all-cause 6-month readmission rates (52% vs. 50%, p=0.05). Even after adjusting for age, gender, CBVD, acute encephalopathy, PVD, coagulopathy, malnutrition, and chronic (liver and renal) diseases, the HFS>5 continued to be associated with higher inpatient mortality compared to those with HFS<5 (OR 2.27[1.69-3], p<0.001). Length of stay had a linear trend with HFS (mean of 25 days for HFS<5 vs. 37 days for HFS 5-10 vs. 50 days for HFS 10-15 vs. 61 days for HFS>15, p<0.001).ConclusionIn patients receiving advanced HF therapy, hospital frailty risk score is associated with worse outcomes. Frailty has been associated with inferior outcomes in patients with advanced heart failure (HF) therapy, which includes heart transplantation and Left Ventricular Assist Device implantation (LVAD). There is a lack of data to assess if hospital frailty risk score (HFS) is associated with worse outcomes in such populations. Our retrospective study used Nationwide Readmission Database (NRD). First, we extracted all cases older than 18 years that received advanced heart failure therapy during the index admission between Jan-Jun for 2016-2019 to allow for a 6-month follow-up. Appropriate survey and domain analyses were applied to obtain national estimates using SAS 9.4. We identified 14,837 discharges who received advanced HF therapy. HFS <5 was present in 25% (n=3,753) of the cohort. Patients with intermediate-high frailty risk score (HFS<=5) were slightly older than those with low frailty risk (HFS<5) with a mean age of 56 years vs. 54 years, and had fewer women (23% vs. 27%, p<0.001). Patients with HFS>5 had a higher prevalence of diabetes mellitus, cerebrovascular disease (CBVD), acute encephalopathy, anemia, coagulopathy, peripheral vascular disease (PVD), and chronic (liver and renal) diseases (p<0.001). Also, they had higher inpatient mortality during index admission (11% vs. 3%, p<0.001), and all-cause 6-month readmission rates (52% vs. 50%, p=0.05). Even after adjusting for age, gender, CBVD, acute encephalopathy, PVD, coagulopathy, malnutrition, and chronic (liver and renal) diseases, the HFS>5 continued to be associated with higher inpatient mortality compared to those with HFS<5 (OR 2.27[1.69-3], p<0.001). Length of stay had a linear trend with HFS (mean of 25 days for HFS<5 vs. 37 days for HFS 5-10 vs. 50 days for HFS 10-15 vs. 61 days for HFS>15, p<0.001). In patients receiving advanced HF therapy, hospital frailty risk score is associated with worse outcomes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wujiwuhui完成签到 ,获得积分10
16秒前
温婉的人雄完成签到,获得积分10
17秒前
xzy998应助依居采纳,获得10
18秒前
zz完成签到 ,获得积分10
29秒前
依居完成签到,获得积分10
29秒前
MISA完成签到 ,获得积分10
37秒前
loga80完成签到,获得积分0
41秒前
49秒前
中中中发布了新的文献求助10
56秒前
XKINGLEE完成签到 ,获得积分10
1分钟前
Sun1c7完成签到,获得积分10
1分钟前
中中中完成签到,获得积分10
1分钟前
科研通AI2S应助竞鹤采纳,获得10
1分钟前
西瓜刀完成签到 ,获得积分10
1分钟前
raiychemj完成签到,获得积分10
1分钟前
DPmmm应助竞鹤采纳,获得10
2分钟前
永不言弃完成签到 ,获得积分10
2分钟前
晴天完成签到 ,获得积分10
2分钟前
Lucas完成签到,获得积分10
2分钟前
穆一手完成签到 ,获得积分10
2分钟前
小鱼女侠完成签到 ,获得积分10
2分钟前
竞鹤完成签到,获得积分10
2分钟前
亮总完成签到 ,获得积分10
2分钟前
闪闪的谷梦完成签到 ,获得积分10
2分钟前
斯文败类应助spark810采纳,获得10
2分钟前
海鹏完成签到 ,获得积分10
2分钟前
研友_89eRG8完成签到,获得积分10
2分钟前
3分钟前
个性仙人掌完成签到 ,获得积分10
3分钟前
尔信完成签到 ,获得积分10
3分钟前
3分钟前
潇潇雨歇发布了新的文献求助10
3分钟前
潇潇雨歇发布了新的文献求助10
3分钟前
3分钟前
潇潇雨歇发布了新的文献求助10
3分钟前
橙子完成签到 ,获得积分10
3分钟前
猫小乐C完成签到,获得积分10
3分钟前
zly完成签到 ,获得积分10
3分钟前
科研通AI2S应助zzf采纳,获得10
4分钟前
XX完成签到 ,获得积分10
4分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052630
求助须知:如何正确求助?哪些是违规求助? 2709863
关于积分的说明 7418232
捐赠科研通 2354395
什么是DOI,文献DOI怎么找? 1246007
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921