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An intoxication involving 2‐methyl AP‐237 and AP‐238 from Victoria, Australia: Case report

急诊科 出版 图书馆学 医学 法学 政治学 护理部 计算机科学
作者
Jacqueline Maplesden,Shaun L Greene,Rebekka Syrjanen,Matthew Di Rago,Jennifer Schumann
出处
期刊:Drug Testing and Analysis [Wiley]
标识
DOI:10.1002/dta.3524
摘要

Drug Testing and AnalysisEarly View CASE REPORT An intoxication involving 2-methyl AP-237 and AP-238 from Victoria, Australia: Case report Jacqueline Maplesden, Jacqueline Maplesden Department of Emergency Medicine, St Vincent's Hospital, Melbourne, AustraliaSearch for more papers by this authorShaun Greene, Corresponding Author Shaun Greene [email protected] Department of Emergency Medicine, Austin Hospital, Melbourne, Australia Victorian Poisons Information Centre, Austin Health, Melbourne, Australia Department of Critical Care, University of Melbourne, Melbourne, Australia Correspondence Shaun Greene, Victorian Poisons Information Centre, Austin Hospital, Melbourne, Australia. Email: [email protected]Search for more papers by this authorRebekka Syrjanen, Rebekka Syrjanen Victorian Poisons Information Centre, Austin Health, Melbourne, Australia Department of Forensic Medicine, Monash University, Melbourne, AustraliaSearch for more papers by this authorMatthew Di Rago, Matthew Di Rago Victorian Institute of Forensic Medicine, Monash University, Melbourne, AustraliaSearch for more papers by this authorJennifer Schumann, Jennifer Schumann Department of Forensic Medicine, Monash University, Melbourne, Australia Victorian Institute of Forensic Medicine, Monash University, Melbourne, Australia Monash Addiction Research Centre, Melbourne, AustraliaSearch for more papers by this author Jacqueline Maplesden, Jacqueline Maplesden Department of Emergency Medicine, St Vincent's Hospital, Melbourne, AustraliaSearch for more papers by this authorShaun Greene, Corresponding Author Shaun Greene [email protected] Department of Emergency Medicine, Austin Hospital, Melbourne, Australia Victorian Poisons Information Centre, Austin Health, Melbourne, Australia Department of Critical Care, University of Melbourne, Melbourne, Australia Correspondence Shaun Greene, Victorian Poisons Information Centre, Austin Hospital, Melbourne, Australia. Email: [email protected]Search for more papers by this authorRebekka Syrjanen, Rebekka Syrjanen Victorian Poisons Information Centre, Austin Health, Melbourne, Australia Department of Forensic Medicine, Monash University, Melbourne, AustraliaSearch for more papers by this authorMatthew Di Rago, Matthew Di Rago Victorian Institute of Forensic Medicine, Monash University, Melbourne, AustraliaSearch for more papers by this authorJennifer Schumann, Jennifer Schumann Department of Forensic Medicine, Monash University, Melbourne, Australia Victorian Institute of Forensic Medicine, Monash University, Melbourne, Australia Monash Addiction Research Centre, Melbourne, AustraliaSearch for more papers by this author First published: 30 May 2023 https://doi.org/10.1002/dta.3524 Funding information: This project was funded by the Victorian Department of Health and Human Services and a National Health and Medical Research Council Ideas Grant (APP 2001107). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES 1 United Nations Office on Drugs and Crime (UNODC). World drug report 2021. 2021. https://www.unodc.org/unodc/data-and-analysis/wdr2021.html Accessed 1 May 2023. 2Resnik K, Brandao P, Alves EA. DARK classics in chemical neuroscience: bucinnazine. ACS Chem Nerosci. 2021; 12(19): 3527- 3534. doi:10.1021/acschemneuro.1c00522 3 National Forensic Laboratory Slovenia. Analytical report 2-methyl AP-237 (C18H26N20). 19 March 2019. https://www.deadiversion.usdoj.gov/dea_tox/announcements/2-Methyl_AP-237.pdf Accessed 1 May 2023. 4 European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). European drug report 2020. 2020. https://www.emcdda.europa.eu/system/files/publications/13236/TDAT20001ENN_web.pdf Accessed 17 July 2022. 5Fogarty MF, Vandeputte MM, Krotulski AJ, et al. Toxicological and pharmacological characterization of novel cinnamylpiperazine synthetic opioids in humans and in vitro including 2-methyl AP-237 and AP-238. Arch Toxicol. 2022; 96(6): 1701- 1710. doi:10.1007/s00204-022-03257-7 6 Discovery N. NPS opioids in the United States trend report: Q3 2021—NPS Discovery. 2021. https://www.cfsre.org/nps-discovery/trend-reports Accessed 17 July 2022. 7 The Centre for Forensic Science and Education (CFSRE) Monograph: AP-238 November 11, 2020b. 2020. https://www.cfsre.org/nps-discovery/monographs/ap-238 Accessed 6 May 2023. 8Darke S, Peacock A, Duflou J, Farrell M, Lappin J. Characteristics of fatal ‘novel’ synthetic opioid toxicity in Australia. Drug Alcohol Depend. 2022; 232:109292. doi:10.1016/j.drugalcdep.2022.109292 9Lamy FR, Daniulaityte R, Barratt MJ, Lokala U, Sheth A, Carlson RG. “Etazene, safer than heroin and fentanyl”: non-fentanyl novel synthetic opioid listings on one darknet market. Drug Alcohol Depend. 2021; 225:108790. doi:10.1016/j.drugalcdep.2021.108790 10Di Rago M, Pantatan S, Hargreaves M, et al. High throughput detection of 327 drugs in blood by LC-MS-MS with automated data processing. 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Annex 1. 45th WHO ECDD summary assessments, findings and recommendations, 10–13 October 2022 Substances to be added to Schedule I of the Single Convention on Narcotic Drugs (1961) 2022. 16 World Health Organisation (WHO). Critical review report: 2-methyl AP-237. Expert Committee on Drug Dependence. Forty-fifth Meeting Geneva, 10–14 October 2022. 2022. https://cdn.who.int/media/docs/default-source/controlled-substances/45th-ecdd/2-methyl-ap-237_draft.pdf?sfvrsn=768c7c03_1 Accessed 1 May 2023. 17Kassai S, Pintér JN, Rácz J, et al. Assessing the experience of using synthetic cannabinoids by means of interpretative phenomenological analysis. Harm Reduct J. 2017; 14(1): 9. doi:10.1186/s12954-017-0138-1 18Sutter ME, Gerona RR, Davis MT, et al. Fatal fentanyl: one pill can kill. Acad Emerg Med. 2017; 24(1): 106- 113. doi:10.1111/acem.13034 19Gerostamoulos D, Elliott S, Walls HC, Peters FT, Lynch M, Drummer OH. To measure or not to measure? That is the NPS question. J Anal Toxicol. 2016; 40(4): 318- 320. doi:10.1093/jat/bkw013 20Schicchi A, Brambilla E, Bernasconi L, Papa P, Valli A, Buscaglia E, Novelli MT, Moruno PG, Locateli CA. A case of crack-lung-like syndrome due to new synthethic opioid consumption with analytical confirmation (Abstract 323). Paper presented at: European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 2021; Virtual meeting. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1254235 Accessed: 1 May 2023 21Skolnick P. Treatment of overdose in the synthetic opioid era. Pharmacol Ther. 2022; 233:108019. doi:10.1016/j.pharmthera.2021.108019 22 United Nations Office on Drugs and Crime (UNODC). Current NPS threats (November 2021). Volume IV. 2021. https://www.unodc.org/documents/scientific/Current_NPS_Threats_Vol.3.pdf Accessed: 1 May 2023 23 Coroners Court of Victoria: Coroners Prevention Unit. Victorian overdose deaths 2011–2020. 2021. https://www.coronerscourt.vic.gov.au/victorian-overdose-deaths-2011-2020 Accessed 1 May 2023. 24Schumann JL, Syrjanen R, Alford K, et al. Intoxications in an Australian emergency department involving ‘Nitazene’ benzylbenzimidazole synthetic opioids (etodesnitazene, butonitazene and protonitazene). J Anal Toxicol. 2023; 47(1): e6- e9. doi:10.1093/jat/bkac062 25Papsun DM, Krotulski AJ, Logan BK. Proliferation of novel synthetic opioids in postmortem investigations after Core-structure scheduling for fentanyl-related substances. Am J Forensic Med Pathol. 2022; 43(4): 315- 327. doi:10.1097/PAF.0000000000000787 Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation

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