Type-I Supramolecular Photosensitizer Enables GSH Depletion by Hydrogen Atom Transfer

concurrently reduces molecular oxygen to superoxide radicals. As a result, this photosensitizer exhibits remarkable photocytotoxicity and significant antitumor efficacy in mouse models. This work offers a strategy for synergistically photocatalytic oxidation of antioxidants and generation of reactive oxygen species for PDT.