A Comprehensive Review on Oleic Acid Vesicles: A Novel Approach to Drug Delivery

The implementation of several innovative drug delivery technologies has made medication distribution more focused and managed in recent years. These days, a vesicular drug delivery system defines the rate of distribution and the site of action in order to improve the action and increase patient compliance; there are various kinds of newly developed vesicular drug delivery systems, including transferosomes, niosomes, aquasomes, ufasomes, pharmacosomes, and phytosomes. Ufasomes are unsaturated fatty acid vesicles with a limited pH range of 7 to 9. They are a suspension of closed lipid bilayers made of fatty acids and their ionized species. The hydrocarbon tails of fatty acid molecules are oriented toward the membrane's inner core, and their carboxyl groups are in contact with water. The two fatty acids that are most frequently employed in the ufasomes’ manufacturing process are oleic and linoleic acids. It is a common practice to produce fatty acid vesicles via the thin film hydration process. The manufacture of stable ufasomes is mostly dependent on the choice of fatty acids, amount of cholesterol, pH range, buffer, etc. This article goes into additional detail regarding unsaturated fatty acids’ characteristics, benefits, and drawbacks.