去抑制
眶额皮质
功能连接
神经科学
心理学
后顶叶皮质
额叶
前额叶皮质
认知
作者
Shaorui Wang,Jinfeng Han,Mingyue Xiao,Pan Shi,Hong Chen
标识
DOI:10.1093/cercor/bhae314
摘要
Abstract Disinhibition, characterized by a loss of dietary control, is a significant risk factor for diet failure and the onset of eating disorders in restrained eaters. This study employs resting-state functional connectivity and structural covariance network analyses to explore the neural associations underlying this behavior. By analyzing functional MRI data from 63 female college students, we found that increased disinhibition correlates with enhanced functional connectivity between the medial orbitofrontal cortex and key components of the inhibition system, particularly within the fronto-parietal network. Moreover, we observed a relationship between the structural covariance of the medial orbitofrontal cortex and the inferior parietal lobule and the severity of disinhibition. Importantly, the functional connectivity between the medial orbitofrontal cortex and the inferior parietal lobule predicts the severity of binge eating symptoms in these individuals. These findings indicate that imbalances in the interaction between the brain’s reward and inhibition systems can lead to dietary failures and eating disorders, emphasizing the need for targeted interventions.
科研通智能强力驱动
Strongly Powered by AbleSci AI