痴呆
危险系数
医学
四分位数
血管性痴呆
置信区间
空气污染
入射(几何)
比例危险模型
环境卫生
疾病
内科学
光学
物理
有机化学
化学
作者
Guo‐Chong Chen,Daniel Nyarko Hukportie,Wan Zhongxiao,Furong Li,Xianbo Wu
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2022-11-24
卷期号:78 (12): 2309-2317
被引量:3
标识
DOI:10.1093/gerona/glac228
摘要
Abstract Background The influence of overall air pollution on dementia risk and the potential effect modification by other risk factors remain to be clarified. Methods We included 459 844 UK residents who were free of dementia and had data on the exposure to particulate matter (PM)2.5, PM2.5–10, PM10, NO2, and NOx during baseline recruitment. The combined exposure to various PMs and NOx was estimated by using an air pollution score. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident dementia were estimated by multivariable Cox models. Results During a median 11.7 years follow-up, 5 905 incident cases of all-cause dementia were identified. With the exception of PM2.5–10, all other air pollutants were separately associated with a higher risk of all-cause dementia (all p-trend < .001) with generally similar associations for dementia subtypes. An increasing air pollution score was associated with higher risks of all-cause as well as individual dementia outcomes, with adjusted HRs (95% CI) of 1.27 (1.18, 1.37) for all-cause dementia, 1.27 (1.14, 1.43) for Alzheimer’s disease, and 1.35 (1.16, 1.57) for vascular dementia when comparing the highest with the lowest quartile of the score (all p-trend < .001). These associations of air pollution score with dementia and its subtypes were observed among never and former smokers but not among current smokers (all p-interaction 
< .030). Conclusion Air pollution was associated with a higher risk of dementia among nonsmokers but not current smokers. Additional studies are required to confirm our findings and to explore the potential mechanisms underlying the possible effect modification by smoking status.
科研通智能强力驱动
Strongly Powered by AbleSci AI