化学
双金属片
芳基
催化作用
钪
组合化学
产量(工程)
协同催化
反应条件
药物化学
有机化学
冶金
材料科学
烷基
作者
Jun‐An Xiao,Hai Peng,Huan Zhang,Ru-Fang Meng,Chenxiang Lin,Wei Su,Yanmin Huang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-18
卷期号:24 (47): 8709-8713
被引量:3
标识
DOI:10.1021/acs.orglett.2c03679
摘要
The diastereoselective assembly of spiroindolenines via a synergistic scandium/gold-catalyzed dearomative spiroannulation is herein described. This protocol offers access to a wide variety of spiroindolenine derivatives in 86% average yield with moderate to excellent diastereoselectivities (up to 97:3 dr). The control experimental studies lend support to the bimetallic relay catalysis. Moreover, the scale-up reaction and synthetic transformations of spiroindolenine product further demonstrate its synthetic utility.
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