自愈水凝胶
材料科学
细胞外基质
再生(生物学)
组织工程
纳米技术
体内
生物物理学
化学工程
化学
生物医学工程
细胞生物学
高分子化学
生物化学
医学
生物技术
生物
工程类
作者
Zhenming Wang,Jin Zhao,Wanze Tang,Liqiu Hu,Xin Chen,Yiping Su,Chang Zou,Jianhong Wang,William W. Lu,Wu Zhen,Ronghua Zhang,Dazhi Yang,Songlin Peng
出处
期刊:Small
[Wiley]
日期:2019-08-18
卷期号:15 (41)
被引量:89
标识
DOI:10.1002/smll.201901560
摘要
Abstract Tissue‐engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) hydrogels with tunable mechanical properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) hydrogels are constructed by addition of ultrathin 2D black phosphorus (BP) nanosheets to the DN hydrogels with multiple functions for mimicking the ECM microenvironment to induce tissue regeneration. Notably, it is found that the BP nanosheets exhibit intrinsic properties for induced CaP crystal particle formation and therefore improve the mineralization ability of NE hydrogels. Finally, in vitro and in vivo data demonstrate that the BP nanosheets, mineralized CaP crystal nanoparticles, and excellent mechanical properties provide a favorable ECM microenvironment to mediate greater osteogenic cell differentiation and bone regeneration. Consequently, the combination of bioactive chemical materials and excellent mechanical stimuli of NE hydrogels inspire novel engineering strategies for bone‐tissue regeneration.
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