子宫内膜
激素
子宫内膜异位症
月经
自噬
雌激素
免疫
医学
生理学
内科学
内分泌学
生物
免疫系统
免疫学
细胞凋亡
生物化学
作者
Hui‐Hui Shen,Tao Zhang,Hui‐Li Yang,Zhen‐Zhen Lai,Wen‐Jie Zhou,Jie Mei,Jing Shi,Rui Zhu,Feng-Yuan Xu,Da‐Jin Li,Jiang‐Feng Ye,Ming‐Qing Li
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2021-01-01
卷期号:11 (7): 3512-3526
被引量:33
摘要
Menstruation occurs in few species and involves a cyclic process of proliferation, breakdown and regeneration under the control of ovarian hormones. Knowledge of normal endometrial physiology, as it pertains to the regulation of menstruation, is essential to understand disorders of menstruation. Accumulating evidence indicates that autophagy in the endometrium, under the regulation of ovarian hormones, can result in the infiltration of immune cells, which plays an indispensable role in the endometrium shedding, tissue repair and prevention of infections during menstruation. In addition, abnormal autophagy levels, together with resulting dysregulated immune system function, are associated with the pathogenesis and progression of endometriosis. Considering its potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders, we review the activity and function of autophagy during menstrual cycles. The role of the estrogen/progesterone-autophagy-immunity axis in endometriosis are also discussed.
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