BippyPhos: A Highly Versatile Ligand for Pd‐Catalyzed C−N, C−O and C−C Couplings

Numerous ligands have been designed for the Buchwald-Hartwig Amination (BHA). Among the ligands developed is BippyPhos. This ligand was originally designed to enable a coupling of primary amines with aryl halides. Further studies showed that the ligand has fairly broad utility for Pd-catalyzed C−N, C−O and C−C couplings. This review describes the various Pd-catalyzed applications involving BippyPhos as a supporting ligand. While BippyPhos may not often be the most optimal ligand for various Pd-catalyzed couplings, it typically will provide adequate results as a starting point prior to screening for optimization.