mTORC1型
PI3K/AKT/mTOR通路
生物
自噬
细胞生物学
雷帕霉素的作用靶点
溶酶体
生物发生
信号转导
细胞内
P70-S6激酶1
mTORC2型
TOR信号
合成代谢
RPTOR公司
核糖体生物发生
遗传学
生物化学
基因
核糖核酸
核糖体
细胞凋亡
酶
作者
Kendall J. Condon,David M. Sabatini
摘要
The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental and intracellular cues to control eukaryotic cell growth. As a pivot point between anabolic and catabolic processes, mTOR complex 1 (mTORC1) signaling has established roles in regulating metabolism, translation and autophagy. Hyperactivity of the mTOR pathway is associated with numerous human diseases, including diabetes, cancer and epilepsy. Pharmacological inhibition of the mTOR pathway can extend lifespan in a variety of model organisms. Given its broad control of essential cellular processes and clear relevance to human health, there is extensive interest in elucidating how upstream inputs regulate mTORC1 activation. In this Cell Science at a Glance article and accompanying poster, we summarize our understanding of how extracellular and intracellular signals feed into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis.
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