A Practical Method for the Preparation of Sulfonyl Chlorides and Sulfonamides from Thiols using H2O2‐TAPC Reagent System

Abstract H 2 O 2 in the presence of TAPC (1,3,5‐triazo‐2,4,6‐triphosphorine‐2,2,4,4,6,6‐chloride) as an effective and chemoselective reagent system is described for the direct conversion of thiols to sulfonyl chlorides. Upon reaction with amines, the desired sulfonamides were produced in excellent yields and in short reaction times. Mild conditions, metal‐free process, and excellent selectivity are some of the advantages of this method.