聚合物囊泡
抗菌活性
自愈水凝胶
材料科学
青霉素
壳聚糖
抗菌肽
组合化学
化学
高分子化学
抗生素
细菌
复合材料
有机化学
生物化学
共聚物
聚合物
生物
两亲性
遗传学
作者
Yuanxiu Hong,Yuejing Xi,Junxue Zhang,Dongdong Wang,Hailong Zhang,Ning Yan,Shisheng He,Jianzhong Du
摘要
We present an antibacterial polymersome-hydrogel composite that combines the advantages of both antimicrobial peptides and antibiotics. The polymersomes are self-assembled from poly(ε-caprolactone)-block-poly(lysine-stat-phenylalanine) [PCL-b-P(Lys-stat-Phe)], exhibiting long-acting intrinsic antibacterial capabilities against both Gram-positive and Gram-negative bacteria. In addition, penicillin is encapsulated into the polymersomes, showing quick and enhanced antibacterial activities. Furthermore, a dynamic hydrogel network is prepared based on the Schiff base linkages between the aldehyde groups of dibenzaldehyde-functionalized PEG (DF-PEG) and the amino groups of chitosan. During this process, the penicillin-loaded polymersomes are grafted into the hydrogel networks by Schiff base linkages to afford polymersome-hydrogel composites, which exhibit two-stage antibacterial behavior: (1) penicillin can be released from the hydrogel networks for quick antibacterial function; (2) the polymersomes and the remaining penicillin can be further released for long-term antibacterial effects. Overall, this polymersome-hydrogel composite represents a new type of injectable antibacterial biomaterial for quick and long-acting antibacterial applications.
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