调节器
生物
癌症研究
免疫系统
抑制器
肿瘤微环境
癌变
效应器
肿瘤进展
免疫疗法
河马信号通路
转录因子
免疫
髓样
细胞生物学
免疫学
癌症
基因
遗传学
作者
Zhaoji Pan,Ye Tian,Chengsong Cao,Guoping Niu
标识
DOI:10.1158/1541-7786.mcr-19-0375
摘要
Abstract Yes-associated protein (YAP)/WW domain-containing transcription regulator 1 (TAZ) is an important transcriptional regulator and effector of the Hippo signaling pathway that has emerged as a critical determinant of malignancy in many human tumors. YAP/TAZ expression regulates the cross-talk between immune cells and tumor cells in the tumor microenvironment through its influence on T cells, myeloid-derived suppressor cells, and macrophages. However, the mechanisms underlying these effects are poorly understood. An improved understanding of the role of YAP/TAZ in tumor immunity is essential for exploring innovative tumor treatments and making further breakthroughs in antitumor immunotherapy. This review primarily focuses on the role of YAP/TAZ in immune cells, their interactions with tumor cells, and how this impacts on tumorigenesis, progression, and therapy resistance.
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