腺苷受体
腺苷酸
肺
肺纤维化
受体
医学
重症监护医学
内科学
兴奋剂
作者
Veronica Della Latta,Manuela Cabiati,Silvia Rocchiccioli,Silvia Del Ry,Maria‐Aurora Morales
标识
DOI:10.1016/j.phrs.2013.08.004
摘要
Adenosine (ADO) is a retaliatory metabolite that is expressed in conditions of injury or stress. During these conditions ATP is released at the extracellular level and is metabolized to adenosine. For this reason, adenosine is defined as a “danger signal” for cells and organs, in addition to its important role as homeostatic regulator. Its physiological functions are mediated through interaction with four specific transmembrane receptors called ADORA1, ADORA2A, ADORA2B and ADORA3. In the lungs of mice and humans all four adenosine receptors are expressed with different roles, having pro- and anti-inflammatory roles, determining bronchoconstriction and regulating lung inflammation and airway remodeling. Adenosine receptors can also promote differentiation of lung fibroblasts into myofibroblasts, typical of the fibrotic event. This last function suggests a potential involvement of adenosine in the fibrotic lung disease processes, which are characterized by different degrees of inflammation and fibrosis. Idiopathic pulmonary fibrosis (IPF) is the pathology with the highest degree of fibrosis and is of unknown etiology and burdened by lack of effective treatments in humans.
科研通智能强力驱动
Strongly Powered by AbleSci AI