生物传感器
石墨烯
离子液体
材料科学
纳米材料
检出限
纳米技术
表面改性
电化学
化学
离子键合
氧化物
电极
色谱法
有机化学
物理化学
离子
催化作用
冶金
作者
Xianbo Lu,Xue Wang,Jing Jin,Qing Zhang,Jiping Chen
标识
DOI:10.1016/j.bios.2014.06.036
摘要
In this study, a facile non-covalent method was developed for preparing water-soluble graphene with excellent electronic conductivity. Room temperature ionic liquids (ILs) with high ionic conductivity were used for the non-covalent surface functionalization of graphene through π–π stacking interactions. Compared to other ILs used, amino acid ionic liquids (AAILs) were found to be the most effective for improving the dispersion of graphene in water phase. Electrochemical and spectroscopic results confirmed that the obtained AAIL functionalized GR can retain the excellent electronic conductivity of pristine graphene without damaging the graphene lattice. The obtained water-soluble graphene (GR-AAIL) was exemplified to fabricate an electrochemical biosensor using tyrosinase as a model enzyme, and the sensitivity (12,600 mA cm−2 M−1) of GR-AAIL based biosensor was about 17 times higher than that of graphene oxide and other nanomaterial based biosensor, displaying its unprecedented high sensitivity for biosensing. The detection limit for catechol (one important environmental pollutant) reached as low as 8 nM with a response time of 3 s and a linear range from 25 nM to 11,100 nM. The AAIL-GR based biosensor also demonstrated good reproducibility, repeatability, selectivity, long-term stability and high recovery for catechol detection. Amino acid ionic liquid functionalized graphene proves to be a robust and versatile electrochemical biosensing platform for fabricating biosensors with excellent performance.
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