生物钟
串扰
昼夜节律
生物
细胞生物学
转录因子
NAD+激酶
奶油
安普克
激酶
蛋白激酶A
生物化学
神经科学
酶
基因
物理
光学
作者
Gad Asher,Ueli Schibler
标识
DOI:10.1016/j.cmet.2011.01.006
摘要
In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK, NPAS2, and HSF1), nutrient-sensing transcriptional regulatory proteins (e.g., CREB-CBP-CRCT2, FOXO-p300, nuclear receptors, PGC-1, and SP1 family members) and protein kinases (e.g., AMPK), are plausible candidates for conveying a cell's metabolic state to the core clock circuitry. The intertwining between these acute regulators and circadian clock components is so tight that the discrimination between metabolic and circadian oscillations may be somewhat arbitrary.
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