运动发酵单胞菌
戊糖
木糖
磷酸戊糖途径
发酵
生物化学
代谢工程
化学
转酮酶
木糖代谢
乙醇发酵
糖
木质纤维素生物量
乙醇燃料
新陈代谢
酶
糖酵解
作者
Min Zhang,C K Eddy,K Deanda,Mark Finkelstein,Stephen Picataggio
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1995-01-13
卷期号:267 (5195): 240-243
被引量:659
标识
DOI:10.1126/science.267.5195.240
摘要
The ethanol-producing bacterium Zymomonas mobilis was metabolically engineered to broaden its range of fermentable substrates to include the pentose sugar xylose. Two operons encoding xylose assimilation and pentose phosphate pathway enzymes were constructed and transformed into Z. mobilis in order to generate a strain that grew on xylose and efficiently fermented it to ethanol. Thus, anaerobic fermentation of a pentose sugar to ethanol was achieved through a combination of the pentose phosphate and Entner-Doudoroff pathways. Furthermore, this strain efficiently fermented both glucose and xylose, which is essential for economical conversion of lignocellulosic biomass to ethanol.
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